Logitech Signature M650: A quiet wireless mouse for big, small, or left hands

Many mice offer very basic functionality—left-click, right-click, scroll wheel, and not much more. Others boast a range of programmable buttons, premium sensor specs, USB-C charging, and other features for power users. But what if you don’t need that extreme level of functionality but don’t want something cheap and bare-bones, either?

Released this past week, the Logitech Signature M650 wireless mouse is a middle-ground device that supports Windows, macOS, Linux, Chrome OS, iPadOS, and Android. It doesn’t have the most advanced features, but it isn’t basic, either. And by skipping some add-ons, like multiple Bluetooth profiles, the mouse is able to maintain an affordable $40 price point.

Logitech’s latest cord-free mouse also comes in three different versions: a standard size, a large size, and a large left-handed version, providing something for everyone—unless you have a smaller left hand, that is.

Different hands and sizes

Logitech makes it easy to determine which version is the best for you. Those with small- to medium-sized hands, which measure up to 7.5 inches, should get the standard M650, while those with hands longer than 7.5 inches should opt for the M650 L.

If you have tiny hands and want a similar wireless mouse, there are smaller options, like the Razer Pro Click Mini (3.9×2.5×1.3 inches, 3.1 ounces with one battery).

The medium-size version is 4.22×2.43×1.49 inches and 3.57 ounces. That makes it a bit smaller in length and width (but noticeably heavier) than Logitech’s Pop Mouse (4.5×2.6×1.4 inches and 2.9 ounces), another wireless Logitech mouse with a $40 MSRP.

The large M650 (4.65×2.58×1.63 inches, 3.92 ounces) is 10.19 percent longer and 9.8 percent heavier than the standard-sized version I tested. That’s pretty large for a wireless productivity mouse.

It’s even bigger than the Corsair Katar Pro wireless gaming mouse ($40 MSRP), which measures 4.56×2.53×1.49 inches and weighs 3.39 ounces. There are bulkier wireless mice, though, including some from Logitech. The similarly shaped and lower-priced Logitech M510 (4.72×2.56×1.6 inches, 4.55 ounces) is so heavy it feels clunky to use.

There’s a left-handed version of the M650—the side buttons are on the right side of the mouse—but it’s only available in the large size. Wireless left-handed mice are hard to find—there’s the $100 Logitech G903, plus less traditional mice, like ergonomic mice and Microsoft’s Surface Arc. But for a mainstream wireless mouse targeting productivity, this left-handed option is a rare treat.

Having this many options makes it easier for people to find a good fit, especially if they don’t already have preferences in their mouse form factor. There are mice that take size customization to the extreme, but the M650 should provide enough options for most people.

According to Logitech’s chart, I have a medium-sized hand. My typical claw grip felt good with the M650, as my thumb and ring and pinky fingers found strong grip on the mouse’s textured sides. Meanwhile, my thumb could move up and activate both side buttons nearly effortlessly. My pointer and middle fingers naturally fit in the downward slope of the primary buttons, but keeping them in my preferred position for rapid clicks required more effort to stop my hand from slipping down.

I wasn’t as inclined to use my secondary grip type, a palm grip, on the M650 because of its smaller length. My pointer and middle fingers drooped significantly over the top edge with a palm grip, making navigating the left and right clicks more difficult. But the mouse’s large hump helped with comfort.